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Description |
Dihexa (developmental code name PNB-0408), also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. The compound has been found to potently improve cognitive function in animal models of Alzheimer's disease-like mental impairment. In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor. |
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Uses |
N-Hexanoic-Try-Ile-(6)-amino Hexanoic amide (Dihexa) is an angiotensin IV analog as a procognitive/antidementia agent. |
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benefits |
As a new drug, Dihexa has been highly seen to help people experiencing Alzheimer's Disease.Thus, it's main function is to relieve and supplement people who are stricken by this Disease to slow down the progression of Alzheimer's.The best thing about Dihexa is its ability to be able to repair damages found in the synapse that is just between the neurons.Here are some of the benefits of Dihexa:Helps people having Alzheimer's Disease and those with Parkinson's DiseaseCan increase your mental staminaCan improve creative thinking skillsCan enhance conversational skillsCan improve one's ability to solve problemsCan help in managing depressionImproves memoryDihexa also helps one improve focus and learning. That's why this is good most, especially for people who study too.It can even improve heart health, and also boost medical endurance.People who use Dihexa have had testimonies of how this peptide has helped improve their creativity, thinking, and even problem-solving skills.Although you must keep in mind that despite the benefits of Dihexa, it still has some side effects that you must be aware of primarily when it is being regularly used.One who even stops using Dihexa can have severe withdrawal effects once they decide to discontinue using this peptide. Some side effects could be unexpected jitters or even irritability. |
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Biological Activity |
Dihexa is an orally active, blood-brain barrier-permeable angiotensin IV analog; exhibits high affinity binding hepatocyte growth factor (HGF) with a Kd of 65 pM.Dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering. Further, dihexa and Nle1-AngIV induce hippocampal spinogenesis and synaptogenesis similar to HGF itself. Dihexa effectively inhibits HGF dimerization at 1 μM. While dihexa at 1 nM and 10 pM alone does not activate c-Met, it markedly augments the capacity of HGF at 1.25 and 2.5 ng/mL to activate c-Met.Dihexa has a long circulating half-life. Dihexa exhibits procognitive activity. Dihexa reverses scopolamine-dependent spatial learning deficits. It improves spatial learning in aged rats. Dihexa induces spinogenesis in cultured hippocampal neurons. |
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Clinical Use |
Dihexa is a peptide variant derived from angiotensin IV which has been found to potently improve cognitive function in animal models of disease such as Alzheimer’s. Angiotensin IV is a derivative of the potent vasoconstrictor angiotensin II and has been shown to enhance acquisition, consolidation, and recall of learning and memory in animal models when administered centrally or peripherally. In an essay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than BDNF. It could possibly help in the repair of the brain and nerves in neurological disease. |
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Mode of action |
Being a first-class compound that is orally active, Dihexa works through penetrating the blood-brain barriers. This also works through facilitating one's memory consolidation and even memory retrieval.Researchers have seen how this peptide is very active. It also shows a very promising characteristic in terms of overcoming any memory and motor dysfunction. |
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Toxicity evaluation |
According to a patent, "Short duration safety studies with Dihexa have uncovered no apparent toxicity. Of particular note is a lack of neoplastic induction, since c-Met is recognized as an oncogene. This is unsurprising since oncogenesis requires multiple mutations including both oncogene induction and tumor suppressor attenuation." |
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Who Evaluation |
Evaluation year: 2010 |
Quality products make an important contribution to long-term revenue and profitability. Sale Buy Quality Ethyl 2-phenylacetoacetate 5413-05-8 On Stock
The CAS number of ETHYL 2-PHENYLACETOACETATE is 5413-05-8.
Synonyms for ETHYL 2-PHENYLACETOACETATE 5413-05-8:2-Phenylacetoacetic acid ethyl ester;
Ethyl 2-Phenylacetoacetate is used in preparation of iridium polysubstituted quinoline diketonate complex and application as OLED.
InChI:InChI=1/C12H14O3/c1-3-15-12(14)11(9(2)13)10-7-5-4-6-8-10/h4-8,11H,3H2,1-2H3/t11-/m1/s1
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Substituted phenyl pyrazolone derivatives and preparation and application (by machine translation) |
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Henan Xiaguo Biotechnology Co., Ltd. is a quality supplier of ETHYL 2-PHENYLACETOACETATE. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on ETHYL 2-PHENYLACETOACETATE 5413-05-8.
Quality products make an important contribution to long-term revenue and profitability. Sale Chinese Factory Supply Lidocaine 137-58-6 Efficient Delivery
solid
ChEBI: Lidocaine is the monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline. It has a role as a local anaesthetic, an anti-arrhythmia drug, an environmental contaminant, a xenobiotic and a drug allergen. It is a monocarboxylic acid amide, a tertiary amino compound and a member of benzenes. It derives from a glycinamide.
Lidocaine [2-(diethylamino)-N-(2, 6-dimethylphenyl) acetamide monohydrochloride] is the most commonly used amino amide-type local anesthetic. Lidocaine is very lipid soluble and, thus, has a more rapid onset and a longer duration of action than most amino ester-type local anesthetics, such as procaine and tetracaine. It can be administered parenterally (with or without epinephrine) or topically either by itself or in combination with prilocaine or etidocaine as a eutectic mixture that is very popular with pediatric patients. The use of lidocaine–epinephrine mixtures should be avoided, however, in areas with limited vascular supply to prevent tissue necrosis. Lidocaine also frequently is used as a class IB antiarrhythmic agent for the treatment of ventricular arrhythmias, both because it binds and inhibits sodium channels in the cardiac muscle and because of its longer duration of action than amino ester-type local anesthetics. Central nervous system changes are the most frequently observed systemic toxicities of lidocaine. The initial manifestations are restlessness, vertigo, tinnitus, slurred speech, and eventually, seizures. Subsequent manifestations include CNS depression with a cessation of convulsions and the onset of unconsciousness and respiratory depression or cardiac arrest. This biphasic effect occurs because local anesthetics initially block the inhibitory GABAergic pathways, resulting in stimulation, and eventually block both inhibitory and excitatory pathways (i.e., block the sodium channels associated with the NMDA receptors, resulting in overall CNS inhibition).
The CAS number of Lidocaine is 137-58-6.
Synonyms for Lidocaine 137-58-6:2',6'-Acetoxylidide,2-(diethylamino)- (8CI);2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide;Antrolin;Cuivasil;Dalcaine;ELA-Max;Esracaine;Isicaine;Jetocaine;Leostesin;Lidocadren;Lidoderm;Linisol;Maricaine;Penles;Remicaine;Solarcaine;Solcain;Xilina;Xycaine;Xyline;Xylocaine;Xylocitin;a-Diethylamino-2,6-acetoxylidide;
Antiarrhythmic Agents, Anesthetics；Anticonvulsant；antihypertensive
Experimentally, lidocaine has been found to prevent VF arising during myocardial ischemia or infarction by preventing the fragmentation of organized largewavefronts into heterogeneous wavelets. Although lidocaine is of proven benefit in preventing VF early after clinical myocardial infarction, there is no evidence that it reduces mortality. To the contrary, lidocaine may increase mortality after myocardial infarction by approximately 40% to 60%.There are no controlled studies of lidocaine in secondary prevention of recurrence of VT or VF. Lidocaine terminates organized monomorphic spontaneous VT or induced sustained VT in only approximately 20% of cases and is less effective than many other antiarrhythmic drugs. In a blinded, randomized study of intravenous lidocaine versus intravenous amiodarone in out-of-hospital VF resistant to defibrillation, lidocaine was associated with half the likelihood of survival to hospital admission compared with amiodarone.
InChI:InChI=1/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)/p+1
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1,3,5-Triazinanes as Formaldimine Surrogates in the Ugi Reaction |
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Direct injection gas chromatographic/mass spectrometric analysis for denatonium benzoate in specific denatured alcohol formulations |
Ng, Lay-Keow,Hupe, Michel,Harnois, Jean,Lawrence, Andre H. , p. 4389 - 4393 (1998) |
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Carboxyesterase polypeptides for amide coupling |
- Page/Page column 65-66; 73-84, (2021/05/28) |
Henan Xiaguo Biotechnology Co., Ltd. is a quality supplier of Lidocaine. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Lidocaine 137-58-6.
High Purity Selank 129954-34-3 Efficient Transportation Cheap Price We provide high quality Selank peptide (CAS 129954-34-3), at a very affordable prices to our customers.
Selank is a synthetic derivative of the tetrapeptide tuftsin that contains a proline-glycine-proline sequence at the C-terminus and has anxiolytic and anti-inflammatory activities. It increases the amplitude and discharge rate of inhibitory postsynaptic currents of neurons in the rat hippocampal CA1 region when used at a concentration of 1 μM. It decreases the level of affective responses and the number of erroneous escape attempts in rats in an acute stress situation, increases orientational-investigative responses of rats in an unfamiliar situation, and reduces the time mice spend immobile in the forced swim test. It increases locomotor activity of high-anxiety Balb/c, but not C57Bl/6, mice in the open field test. Selank (0.01 mg/kg) decreases verticalization induced by apomorphine in mice. It also decreases expression of the inflammation-related genes Il2rg and Xcr1 in mouse spleen after 90 minutes when administered at a dose of 100 μg/kg.
The CAS number of Selank peptide is 129954-34-3.
More information of Selank peptide 129954-34-3 are:
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CAS Number |
129954-34-3 |
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Density |
1.53±0.1 g/cm3(Predicted) |
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Melting Point |
134-136 °C |
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PSA |
0.00000 |
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LogP |
0.00000 |
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Pka |
3.43±0.20(Predicted) |
The chemical formula of Selank peptide is C33H57N11O9 which containing 33 Carbon atoms,57 Hydrogen atoms,11 Nitrogen atoms and 9 Oxygen atoms,and the molecular weight, and the molecular weight of Selank peptide is 0.00000
Selank is a synthetic derivative of the tetrapeptide tuftsin that contains a proline-glycine-proline sequence at the C-terminus and has anxiolytic and anti-inflammatory activities. It increases the amplitude and discharge rate of inhibitory postsynaptic currents of neurons in the rat hippocampal CA1 region when used at a concentration of 1 μM. It decreases the level of affective responses and the number of erroneous escape attempts in rats in an acute stress situation, increases orientational-investigative responses of rats in an unfamiliar situation, and reduces the time mice spend immobile in the forced swim test. It increases locomotor activity of high-anxiety Balb/c, but not C57Bl/6, mice in the open field test. Selank (0.01 mg/kg) decreases verticalization induced by apomorphine in mice. It also decreases expression of the inflammation-related genes Il2rg and Xcr1 in mouse spleen after 90 minutes when administered at a dose of 100 μg/kg.
Relevant articles related to Selank peptide:
Henan Xiaguo Biotechnology Co., Ltd. is a quality supplier of Selank peptide. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Selank peptide 129954-34-3.
Offer Chinese Manufacturer Supply Semax 80714-61-0 Efficient Delivery We supply high quality ACTH (4-7), Pro-Gly-Pro- (CAS 80714-61-0), in stock, factory directly supply to clients, lower prices, more competitiveness.
ACTH (4-7), Pro-Gly-Pro- is , while it's Molecular Formula is C37H51N9O10S.
The CAS number of ACTH (4-7), Pro-Gly-Pro- is 80714-61-0.
More information of ACTH (4-7), Pro-Gly-Pro- 80714-61-0 are:
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Synonyms |
Lys(Z)-OBzl.TosOH;H-Met-Glu-His-Phe-Pro-Gly-Pro;TsOH*H-Lys(Z)-OBzl;Desmodur N 3390 BA;Met-Glu-His-Phe-Pro-Gly-Pro;1,3,5-tris[6-isocyanatohexyl]-2,4,6-trioxo-s-triazine;trimeric hexamethylene diisocyanate;hexamethylene diisocyanate isocyanurate;tris(6-isocyanatohexyl) isocyanurate;1,3,5-Tris(isocyanatohexamethylene)isocyanurate;HMDI trimer;H-MeLeu-OMe;H-Lys(Z)-OBzl*TosOH;L-2-methylleucine methyl ester; |
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CAS Number |
80714-61-0 |
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Molecular Formula |
C37H51N9O10S |
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Molecular Weight |
813.932 |
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Density |
1.391g/cm3 |
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Boiling Point |
1335.2°Cat760mmHg |
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Flash Point |
761.3°C |
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PSA |
325.58000 |
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LogP |
2.71460 |
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Pka |
3.43±0.20(Predicted) |
Semax is a synthetic analogue of the adrenocorticotropic hormone, a hormone responsible for the production of cortisol which in turn regulates glucose and lipid metabolism and helps to maintain blood pressure. In the hippocampus, Semax rapidly elevates the levels of brain-derived neurotrophic factor (BDNF), a protein important in encouraging growth and differentiation of new neurons and synapses. BDNF is active in the hippocampus, cortex, and forebrain and is important for memory, coordination, concentration, and learning. Semax also works to activate the dopaminergic and serotonergic systems to help prime the brain for action and to induce a controlled state of mental stress.
InChI:InChI=1/C37H51N9O10S/c1-57-16-13-24(38)32(50)42-25(11-12-31(48)49)33(51)43-26(18-23-19-39-21-41-23)34(52)44-27(17-22-7-3-2-4-8-22)36(54)46-15-5-9-28(46)35(53)40-20-30(47)45-14-6-10-29(45)37(55)56/h2-4,7-8,19,21,24-29H,5-6,9-18,20,38H2,1H3,(H,39,41)(H,40,53)(H,42,50)(H,43,51)(H,44,52)(H,48,49)(H,55,56)/t24-,25-,26?,27-,28-,29-/m0/s1
Articles related to ACTH (4-7), Pro-Gly-Pro-:
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Article |
Source |
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AN ANALOG OF ACTH4-10 - A LONG-ACTION STIMULATOR OF LEARNING |
Ponomareva-Stepnaya, M. A.,Nezavibat'ko, V. N.,Antonova, L. V.,Andreeva, L. A.,Alfeeva, L. Yu.,et al. , p. 445 - 450 (2007/10/02) |
Henan Xiaguo Biotechnology Co., Ltd. is a quality supplier and manufacturer of ACTH (4-7), Pro-Gly-Pro- . You can buy high quality, low price ACTH (4-7), Pro-Gly-Pro- 80714-61-0 here. Contact us.
High Purity Buy Quality Thymulin 63958-90-7 Reasonable Price We supply high quality SERUM THYMIC FACTOR (CAS 63958-90-7), in stock, factory directly supply to clients, lower prices, more competitiveness.
SERUM THYMIC FACTOR is , while it's Molecular Formula is C33H54N12O15.
The CAS number of SERUM THYMIC FACTOR is 63958-90-7.
More information of SERUM THYMIC FACTOR 63958-90-7 are:
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Synonyms |
Thymulin(pig peptide moiety);Thymulin (swine peptide moiety) (9CI);L-Asparagine,N2-[N-[N-[N-[N2-[N-[N2-[N-(5-oxo-L-prolyl)-L-alanyl]-L-lysyl]-L-seryl]-L-glutaminyl]glycyl]glycyl]-L-seryl]-;Serum thymic factor;Serum thymic factor (porcine);Thymic serumfactor;Thymic serum factor (pig); |
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CAS Number |
63958-90-7 |
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Molecular Formula |
C33H54N12O15 |
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Molecular Weight |
858.863 |
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Density |
1.417 g/cm3 |
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Boiling Point |
1658.9 °C at 760 mmHg |
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Flash Point |
957.1 °C |
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PSA |
451.86000 |
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LogP |
-3.67790 |
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Pka |
3.08±0.10(Predicted) |
InChI:InChI=1/C33H54N12O15/c1-15(39-29(55)18-6-8-24(50)40-18)27(53)42-16(4-2-3-9-34)30(56)45-21(14-47)32(58)43-17(5-7-22(35)48)28(54)38-11-25(51)37-12-26(52)41-20(13-46)31(57)44-19(33(59)60)10-23(36)49/h15-21,46-47H,2-14,34H2,1H3,(H2,35,48)(H2,36,49)(H,37,51)(H,38,54)(H,39,55)(H,40,50)(H,41,52)(H,42,53)(H,43,58)(H,44,57)(H,45,56)(H,59,60)/t15-,16-,17-,18-,19-,20-,21-/m0/s1
Articles related to SERUM THYMIC FACTOR:
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Article |
Source |
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SYNTHESIS OF BLOOD SERUM THYMIC FACTOR AND ITS ANALOGS |
Cerny, Martin,Kasafirek,, Evzen,Rovensky, Jozef,Krepelka, Jiri , p. 2909 - 2918 (2007/10/02) |
Henan Xiaguo Biotechnology Co., Ltd. is a quality supplier and manufacturer of SERUM THYMIC FACTOR . You can buy high quality, low price SERUM THYMIC FACTOR 63958-90-7 here. Contact us.
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