CasNo：57982-77-1
Product Name:Buserelin
Molecular Formula:C60H86N16O13
Appearance:COA
Purity:99%
Buy Reliable Quality Buserelin, Offer 57982-77-1 In Stock
- Molecular Formula:C60H86N16O13
- Molecular Weight:1239.62
- Appearance/Colour:COA
- Refractive Index:1.671
- Boiling Point:845.19°C (rough estimate)
- PKA:9.82±0.15(Predicted)
- PSA：438.27000
- Density:1.43 g/cmsup>3
- LogP:3.12540
Buserelin(Cas 57982-77-1) Usage
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Chemical Properties |
White or slightly yellowish powder, hygroscopic. |
| Description | Buserelin is a synthetic peptide analog of the luteinizing hormone-releasing hormone (LHRH) agonist, and it has various medical applications, particularly in the field of hormone therapy. Buserelin belongs to a class of medications known as LHRH agonists. LHRH is a hormone produced by the hypothalamus in the brain, and it plays a crucial role in regulating the release of other hormones, including luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Buserelin is a synthetic version of LHRH. |
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Uses |
Buserelin is classified as a LH (luteinizing hormone) blocker. It works by inhibiting the release of LH from the pituitary gland. LH is responsible for stimulating the testicles to produce testosterone. Buserelin is primarily used for the treatment of advanced prostate cancer. By reducing testosterone levels, it can slow down the growth of prostate tumors that depend on testosterone. Buserelin can also be used to manage endometriosis, a condition in which tissue similar to the lining of the uterus grows outside the uterus, causing pain and other symptoms. |
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Brand name |
Suprefact (Hoechst-Roussel). |
InChI:InChI=1/C60H86N16O13/c1-7-64-57(87)48-15-11-23-76(48)58(88)41(14-10-22-65-59(61)62)69-51(81)42(24-33(2)3)70-56(86)47(31-89-60(4,5)6)75-52(82)43(25-34-16-18-37(78)19-17-34)71-55(85)46(30-77)74-53(83)44(26-35-28-66-39-13-9-8-12-38(35)39)72-54(84)45(27-36-29-63-32-67-36)73-50(80)40-20-21-49(79)68-40/h8-9,12-13,16-19,28-29,32-33,40-48,66,77-78H,7,10-11,14-15,20-27,30-31H2,1-6H3,(H,63,67)(H,64,87)(H,68,79)(H,69,81)(H,70,86)(H,71,85)(H,72,84)(H,73,80)(H,74,83)(H,75,82)(H4,61,62,65)/t40-,41-,42-,43-,44-,45-,46-,47+,48-/m0/s1
57982-77-1 Relevant articles
GnRH agonist (buserelin) or hCG for ovulation induction in GnRH antagonist IVF/ICSI cycles: a prospective randomized study
P. Humaidan, H. Ejdrup Bredkjær, L. Bungum, M. Bungum, M.L. Grøndahl, L. Westergaard, C. Yding Andersen
, Human Reproduction, Volume 20, Issue 5, 1 May 2005, Pages 1213–1220,
When at least three follicles had reached a size of 17 mm, patients were randomized to ovulation induction with either a single bolus of 0.5 mg buserelin s.c. (Suprefact; Hoechst, Denmark), or 10 000 IU of hCG s.c. (Pregnyl; Organon). Oocyte retrieval was performed 35 h later, followed by either IVF or ICSI.
LH and FSH response of Holstein heifers to fertirelin acetate, gonadorelin and buserelin
J.R. Chenault 1, D.D. Kratzer 2, R.A. Rzepkowski 1, M.C. Goodwin 1
, Theriogenology Volume 34, Issue 1, July 1990, Pages 81-98
Using these criteria fertirelin acetate is 2.5 to 10 times more potent than gonadorelin, whereas buserelin is approximately 10 to 20 times more potent than fertirelin acetate in the bovine for LH and FSH release.
