What is the L-Thyroxine?

L-Thyroxine is Crystalline Solid, while it's Molecular Formula is C15H11I4NO4. Crystalline Solid Thyroxine is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.

What is the CAS number for L-Thyroxine?

The CAS number of L-Thyroxine is 51-48-9.

What is L-Thyroxine (51-48-9) used for?

L-Thyroxine is a synthetic form of the thyroid hormone thyroxine. In vivo, L-thyroxine (0.9 and 2.7 μg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone from the anterior pituitary in mice. It also reverses decreases in levels of circulating thymic serum factor (FTS) and the number of T rosette-forming cells in an old age-induced mouse model of hypothyroidism. Formulations containing L-thyroxine have been used in the treatment of hypothyroidism.InChI:InChI=1/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

What is the L-Thyroxine?

L-Thyroxine is Crystalline Solid, while it's Molecular Formula is C15H11I4NO4. Crystalline Solid Thyroxine is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.

What is the CAS number for L-Thyroxine?

The CAS number of L-Thyroxine is 51-48-9.

What is L-Thyroxine (51-48-9) used for?

L-Thyroxine is a synthetic form of the thyroid hormone thyroxine. In vivo, L-thyroxine (0.9 and 2.7 μg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone from the anterior pituitary in mice. It also reverses decreases in levels of circulating thymic serum factor (FTS) and the number of T rosette-forming cells in an old age-induced mouse model of hypothyroidism. Formulations containing L-thyroxine have been used in the treatment of hypothyroidism.InChI:InChI=1/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

Chinese Manufacturer Supply L-Thyroxine 51-48-9, Wholesale with Competitive Price

CasNo：51-48-9

Product Name:L-Thyroxine

Molecular Formula:C₁₅H₁₁I₄NO₄

Appearance:Crystalline Solid

Purity:99%

Chinese Manufacturer Supply L-Thyroxine 51-48-9, Wholesale with Competitive Price

Molecular Formula:C15H11I4NO4
Molecular Weight:776.875
Appearance/Colour:Crystalline Solid
Vapor Pressure:4.02E-14mmHg at 25°C
Melting Point:235 °C
Refractive Index:1.795
Boiling Point:576.306 °C at 760 mmHg
PKA:2.2(at 25℃)
Flash Point:302.339 °C
PSA：92.78000
Density:2.635 g/cm³
LogP:5.25760

L-Thyroxine (Cas 51-48-9) Usage

Overview	L-thyroxine, also known as T4, is a major hormone produced by the thyroid gland. It is synthesized through the iodination of tyrosines and the coupling of iodotyrosines in the thyroglobulin. Thyroxine is released into the bloodstream after being cleaved from thyroglobulin by proteolysis. It plays a crucial role in regulating various metabolic processes in the body. L-thyroxine is commonly used in medical treatments for conditions such as hypothyroidism, goiter, chronic lymphocytic thyroiditis, myxedema coma, and stupor. L-thyroxine is available in various commercial oral formulations, including tablets, soft gel capsules, and oral solutions, each with its unique advantages and disadvantages. Factors such as pH and coffee intake can affect the dissolution and absorption of levothyroxine formulations.
Chemical Properties	Crystalline Solid
Originator	Synthroid,Flint,US,1953
Uses	L-thyroxine (levothyroxine) is utilized for various medical purposes related to thyroid hormone deficiency and related conditions. It serves as a replacement for thyroid hormones in the body. The dosage of levothyroxine varies depending on factors such as age, underlying health conditions, and the specific condition being treated. It's important to titrate the dosage carefully and monitor patients regularly. Adverse reactions to levothyroxine can occur, and they range from changes in appetite to more serious symptoms like seizures in rare cases. The effects of the drug can also vary depending on the dosage, with small doses having anabolic effects, medium doses stimulating tissue growth and metabolism, and large doses suppressing thyroid gland activity.
Definition	ChEBI: The L-enantiomer of thyroxine.
Brand name	Levo-T (Alara); Levolet (Vintage); Levothroid (Lloyd); Levoxyl (Jones); Novothyrox (Genpharm); Synthroid (Abbott); Unithroid (Stevens J).
Therapeutic Function	Thyroid hormone
Purification Methods	Purification is the same as for the D-isomer above. Likely impurities are tyrosine, iodotyrosine, iodothyroxines and iodide. Dissolve it in dilute ammonia at room temperature, then crystallise it by adding di[] 546 +27.8o (c 5, EtOH). [Harrington et al. Biochem J 39 164 1945, Nahm & Siedel Chem Ber 96 1 1963, Reineke & Turner J Biol Chem 161 613 1945, Chalmers et al. J Chem Soc 3424 1949, Beilstein 14 II 378, 14 III 1566, 14 IV 2373.]

InChI:InChI=1/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

51-48-9 Relevant articles

L-Thyroxine Therapy in Subclinical Hypothyroidism

DAVID S. COOPER, M.D., RACHELLE HALPERN, M.D., LAWRENCE C. WOOD, M.D., ANN A. LEVIN, M.S., E. CHESTER RIDGWAY, M.D.

, Annals of Internal Medicine

In this study, 33 patients with subclinical hypothyroidism were randomly assigned in a double-blind manner to receive placebo or L-thyroxine therapy and were followed for 1 year with thyroid function tests, serum lipid measurements, basal metabolic rate and systolic time interval determinations, and a questionnaire on hypothyroid symptoms. L-Thyroxine therapy may be useful for patients with subclinical hypothyroidism with abnormal myocardial contractility or symptoms consistent with mild hypothyroidism, or both.

Determination of Iodothyronine Absorption and Conversion of L-Thyroxine (T4) to L-Triiodothyronine (T3) using Turnover Rate Techniques

Martin I. Surks, Alan R. Schadlow, Jerrold M. Stock, and Jack H. Oppenheimer

, J Clin Invest. 1973;52(4):805–811.

The absorption of L-thyroxine (T4) and L-triiodothyronine (T3) and the fractional rate of conversion of T4 to T3 were determined from the turnover rates of T4 and T3 in seven patients without endogenous thyroid function during separate treatment periods with these iodothyronines. Serum T3 concentration was measured by a radioimmunoassay procedure in which the iodothyronines are separated from the plasma proteins before incubation with anti-T3 antibody. Metabolic clearance rates were calculated by an integral (noncompartmental) approach since the use of single compartment kinetics led to a 40% overestimation of the metabolic clearance rate of T3.

51-48-9 Upstream products

300-39-0
3,5-diiodo-l-tyrosine
1041-01-6
3,5-diiodo-L-thyronine
1027-28-7
N-acetyl-3,5-diiodo-L-tyrosine
27059-94-5
iodoacetamide

51-48-9 Downstream products

1596-67-4
O-(4-hydroxyphenyl)-3,5-diiodo-L-tyrosine
97738-15-3
N-chloroacetyl-3,5,3',5'-tetraiodo-L-thyronine
32180-11-3
(S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]-propionic acid methyl ester
5817-39-0
L-3,3',5'-triiodothyronine