501-30-4/Kojic acid

Quick Details
Molecular Formula:C6H6O4
Molecular Weight:142.111
Appearance:Tan powder
CasNo:501-30-4

  • Product Details

    CasNo:501-30-4

    Product Name:Kojic acid

    Molecular Formula:C6H6O4

    Appearance:Tan powder

    Purity:99%

    Buy Reliable Best Quality Kojic acid 501-30-4 with Cheapest Price

    • Molecular Formula:C6H6O4
    • Molecular Weight:142.111
    • Appearance/Colour:Tan powder 
    • Melting Point:152-155 °C 
    • Refractive Index:1.4434 (estimate) 
    • Boiling Point:401.7 °C at 760 mmHg 
    • PKA:7.9(at 25℃) 
    • Flash Point:179.9 °C 
    • PSA:70.67000 
    • Density:1.542 g/cm3 
    • LogP:-0.16230 

    Kojic acid(Cas 501-30-4) Usage

    Description

     

    Physicochemical properties

     

    Application and use

     

    Chemical Properties

    tan powder

    Uses

    A naturally occurring chelation agent.

    Definition

    ChEBI: A pyranone that is 4H-pyran substituted by a hydroxy group at position 5, a hydroxymethyl group at position 2 and an oxo group at position 4. It has been isolated from the fungus Aspergillus oryzae.

    Purification Methods

    Crystallise the acid from MeOH (charcoal) by adding Et2O. It sublimes at 150-200o/0.1torr. [Beilstein 18 II 57, 18 III/IV 1145, 18/2 V 516.]

    InChI:InChI=1/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2

    501-30-4 Relevant articles

    Kojic acid applications in cosmetic and pharmaceutical preparations

    Majid Saeedi a, Masoumeh Eslamifar b, Khadijeh Khezri c

    , Biomedicine & Pharmacotherapy Volume 110, February 2019, Pages 582-593

    Kojic acid (KA) has the ability to act as a UV protector, suppressor of hyperpigmentation in human and restrainer of melanin formation, due to its tyrosinase inhibitory activity. Also, KA could be developed as a chemo sensitizer to enhance efficacy of commercial antifungal drugs or fungicides.

    Inhibition mechanism of kojic acid on polyphenol oxidase

    Jon S. Chen, Cheng I Wei, and Marty R. Marshall

    , J. Agric. Food Chem. 1991, 39, 11, 1897–1901

    Since information concerning the mode of action of kojic acid on PPO was still limited, this study was undertaken to elucidate its action on some of these (mushroom, potato, apple, …

    Facile reduction of carboxylic acids to primary alcohols under catalyst-free and solvent-free conditions

    Harinath, Adimulam,Bhattacharjee, Jayeeta,Panda, Tarun K.

    supporting information, p. 1386 - 1389 (2019/02/05)

    We report the development of a facile pr...

    501-30-4 Process route

    5-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)-2-(((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)methyl)-4H-pyran-4-one

    5-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)-2-(((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)methyl)-4H-pyran-4-one

    5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
    501-30-4,123712-78-7

    5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

    Conditions
    Conditions Yield
    With silica gel; In methanol; at 60 ℃; for 3h; Inert atmosphere;
    70%
    5-acetoxy-2-acetoxymethyl-4H-pyran-4-one
    26209-93-8

    5-acetoxy-2-acetoxymethyl-4H-pyran-4-one

    5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
    501-30-4,123712-78-7

    5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

    Conditions
    Conditions Yield
    With sodium methylate; In methanol; for 1h;
    95%
    With methanol; ammonia;
     


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