CasNo：59-42-7
Product Name:Phenylephrine
Molecular Formula:C9H13NO2
Purity:99%
Chinese Factory Supply Top Purity Phenylephrine 59-42-7 with Reasonable Price
- Molecular Formula:C9H13NO2
- Molecular Weight:167.208
- Vapor Pressure:3.18E-05mmHg at 25°C
- Melting Point:171°C
- Refractive Index:-55.5 ° (C=5, 1mol/L HCl)
- Boiling Point:341.1 °C at 760 mmHg
- PKA:pKa 8.9 (Uncertain)
- Flash Point:163.4 °C
- PSA：52.49000
- Density:1.159 g/cm3
- LogP:1.03590
Phenylephrine(Cas 59-42-7) Usage
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Description |
Phenylephrine (CAS 59-42-7) is a synthetic drug that appears as a white or almost white crystalline powder. It shares both chemical and pharmacological similarities with norepinephrine. One of its distinctive characteristics is its strong selectivity for α-adrenoreceptors, particularly α1-adrenoreceptors. Despite its ability to increase the contractibility of blood vessels, phenylephrine is not typically regarded as a cardiostimulant. |
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Uses |
By acting on adrenergic α1 receptors, phenylephrine induces contractions in aortic smooth muscles. Phenylephrine has clinical applications, including its use as an oral decongestant. It acts on adrenergic α1 receptors in nasal arterioles, causing constriction and reducing nasal congestion. It is also employed as a topical nasal decongestant and a mydriatic agent for dilating the pupil in ophthalmology. In some cases, phenylephrine has been used to raise blood pressure and terminate episodes of paroxysmal supraventricular tachycardia, especially when hypotension is also present. |
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Brand name |
Afrin 4 Hour Nasal Spray (Schering-Plough Health Care); Biomydrin (Parke-Davis); Mydfrin (Alcon); Neo-Synephrine (Sterling Health U.S.A.); Nostril (Boehringer Ingelheim);Fenox;Forte;Isopto;Minims;Visadron. |
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target |
adrenergic α1a receptor |
InChI:InChI=1/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1
59-42-7 Relevant articles
Computational and experimental studies on Phenylephrine as anti-corrosion substance of mild steel in acidic medium
Sumayah Bashir a, Abhinay Thakur a, Hassane Lgaz b, Ill-Min Chung b, Ashish Kumar a
, Journal of Molecular Liquids Volume 293, 1 November 2019, 111539
The highest efficiency of 88% was obtained at a 4000 ppm concentration of Phenylephrine at 298 K. Galvanostatic polarization studies revealed that Phenylephrine acted as a mixed type inhibitor. Thermodynamic and kinetic parameters and their effect on inhibition efficiency have also been studied.
The Pharmacological Effects of Phenylephrine are Indirect, Mediated by Noradrenaline Release from the Cytoplasm
Mahmoud Al-Khrasani, David A. Karadi, Anna R. Galambos, Beata Sperlagh & E. Sylvester Vizi
, Neurochemical Research
Phenylephrine (PE) is a canonical α1-adrenoceptor-selective agonist. However, unexpected effects of PE have been observed in preclinical and clinical studies, that cannot be easily explained by its actions on α1-adrenoceptors. The probability of the involvement of α2- and β-adrenoceptors in the effect of PE has been raised.
59-42-7 Process route
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- 94240-17-2
3-Hydroxyphenyl-ω-methylaminoacetophenone hydrochloride
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- 614-03-9
(S)-phenylephrine
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- 59-42-7
Phenylephrin
| Conditions | Yield |
|---|---|
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With potassium hydroxide; hydrogen; [(R)-P-Phos RuCl2 (R)-DAIPEN]; In water; isopropyl alcohol; at 65 ℃; for 1h; under 21002.1 Torr; Product distribution / selectivity;
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~ 70 % ee |
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With hydrogen; [(S)-Cl-MeO-Biphep RuCl2](dmf)n; In methanol; at 75 ℃; for 18h; under 22502.3 Torr; Product distribution / selectivity;
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72 % ee |
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With hydrogen; [RuCl-(S)-P-Phos(p-cymene)]Cl; In methanol; at 75 ℃; for 18h; under 22502.3 Torr; Product distribution / selectivity;
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56 % ee |
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With hydrogen; [(S)-Xyl-P-Phos RuCl(p-cymene)]Cl; In methanol; at 80 - 85 ℃; for 18h; under 22502.3 Torr; Product distribution / selectivity;
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70 % ee |
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With hydrogen; [(R)-P-Phos Ru(acac)2]; In methanol; at 75 ℃; for 18h; under 22502.3 Torr; Product distribution / selectivity;
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47 % ee |
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With potassium hydroxide; hydrogen; tris(triphenylphosphine)ruthenium(II) chloride; (4S)-2-[2-(diphenylphosphino)phenyl]-4-isopropyl-4,5-dihydro-1,3-oxazole; In water; isopropyl alcohol; toluene; at 65 ℃; for 16h; under 21002.1 Torr; Product distribution / selectivity;
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~ 40 % ee |
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With potassium hydroxide; hydrogen; [(R)-MeOBiphep RuCl2 (R)-DAIPEN]; In water; isopropyl alcohol; at 65 ℃; for 1h; under 21002.1 Torr; Product distribution / selectivity;
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~ 70 % ee |
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With potassium hydroxide; hydrogen; [(R)-C3-TunePhos RuCl2 (R)-DAIPEN]; In water; isopropyl alcohol; at 65 ℃; for 1h; under 21002.1 Torr; Product distribution / selectivity;
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~ 70 % ee |
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- 504-76-7
1,3-oxazolidine
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- 59-42-7
Phenylephrin
| Conditions | Yield |
|---|---|
|
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92% |
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92% |
