CasNo：56038-13-2
Product Name:Sucralose
Molecular Formula:C12H19Cl3O8
Appearance:Off-White Amorphous Solid
Purity:99%
Factory Sells 56038-13-2 On Stock, Buy Quality Sucralose
- Molecular Formula:C12H19Cl3O8
- Molecular Weight:397.637
- Appearance/Colour:Off-White Amorphous Solid
- Vapor Pressure:8.79E-21mmHg at 25°C
- Melting Point:125.5oC
- Refractive Index:1.604
- Boiling Point:669.4 °C at 760 mmHg
- PKA:12.52±0.70(Predicted)
- Flash Point:358.7 °C
- PSA：128.84000
- Density:1.69 g/cm3
- LogP:-1.65610
Sucralose(Cas 56038-13-2) Usage
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Description |
Sucralose (1,6 dichloro-1,6-dideoxy-β-d-fructofuranosyl-4-chloro-4-deoxy-α-d-galactopryranoside) is a novel intense sweetener with a potency about 600 times that of sucrose (Hough, 1989). It is a valuable sugar substitute for individuals seeking a sweet taste without the calories of sugar, and its use is regulated and considered safe for human consumption. |
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Chemical Properties |
Sucralose is typically a white to off-white colored, free-flowing, crystalline powder. It is incredibly sweet, having a sweetening power approximately 600 times that of sucrose (table sugar). |
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Uses |
Sucralose is widely used as a sweetening agent in various food and beverage products. It is chosen for its intense sweetness and lack of aftertaste. It can be found in a wide range of items, including sugar-free or reduced-sugar foods, diet beverages, and sugar-free chewing gum. |
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Who Evaluation |
Evaluation year: 1990 |
InChI:InChI=1/C12H19Cl3O8/c13-1-4-7(17)10(20)12(3-14,22-4)23-11-9(19)8(18)6(15)5(2-16)21-11/h4-11,16-20H,1-3H2
56038-13-2 Relevant articles
Bioconversion of sucralose-6-acetate to sucralose using immobilized microbial cells
Chaubey, Asha,Raina, Chand,Parshad, Rajinder,Rouf, Abdul,Gupta, Pankaj,Taneja, Subhash C.
, p. 81 - 86 (2013)
Bioconversion of sucralose-6-acetate to ...
Sucralose metabolism and pharmacokinetics in man
A. Roberts a 1 1, A.G. Renwick a, J. Sims b, D.J. Snodin b
, Food and Chemical Toxicology Volume 38, Supplement 2, July 2000, Pages 31-41
Sucralose was the principal component in the urine together with two more polar components which accounted for only 2.6% of the administered dose (range 1.5 to 5.1% of dose); both metabolites possessed characteristics of glucuronide conjugates of sucralose.
The development and applications of sucralose, a new high-intensity sweetener
I. Knight
, Canadian journal of physiology and pharmacology, 1994
The research leading to the discovery of sweetness in differently halogenated sucrose is described, as well as the development of sucralose and the process of safety testing and government approval. Finally, sucralose properties and applications in Canada's food and beverage industries are discussed.
56038-13-2 Process route
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- 105066-21-5
sucralose-6-acetate
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- 56038-13-2
Sucralose
| Conditions | Yield |
|---|---|
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With methanol; sodium methylate; at 40 - 50 ℃; for 2h;
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95% |
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With methanol; sodium methylate; at 15 - 20 ℃; for 5h;
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86% |
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4-methyl-morpholine; In ethanol; for 3h; pH=9.5; Product distribution / selectivity; Heating / reflux;
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72.4% |
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triethylamine; In methanol; for 7h; pH=13; Product distribution / selectivity; Heating / reflux;
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70.8% |
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tert-butylamine; In methanol; at 20 ℃; for 5h; pH=12; Product distribution / selectivity;
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68% |
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With methanol; acetyl chloride; at 35 - 40 ℃; for 12 - 16h; pH=3.5 - 4; Product distribution / selectivity; Acetate buffer in methanol;
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28% |
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With sodium hydroxide; water; N,N-dimethylammonium chloride; pH=~ 10.5;
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sucralose-6-acetate; With sodium benzoate; sodium hydroxide; In water; N,N-dimethyl-formamide; at 5 - 25 ℃; pH=11.5 - 13.5;
With acetic acid; In water; N,N-dimethyl-formamide; at 0 - 5 ℃; Product distribution / selectivity;
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With calcium hydroxide; In water; N,N-dimethyl-formamide; for 8h; pH=9.5; Product distribution / selectivity;
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sucralose-6-acetate; With methanol; calcium hydroxide; water; pH=9.5;
With sulfuric acid; water; In methanol;
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With calcium hydroxide; water; pH=9.0 - 9.5; Product distribution / selectivity;
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sucralose-6-acetate; With sodium hydroxide; water; In N,N-dimethyl-formamide; at 33 - 40 ℃; for 4 - 8h; pH=10.5 - 11.2;
With hydrogenchloride; water; In N,N-dimethyl-formamide; for 0.25h; pH=5.53 - 7; Product distribution / selectivity;
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sucralose-6-acetate; With magnesium hydroxide; sodium hydroxide; water; In N,N-dimethyl-formamide; at 40 ℃; for 3h; pH=8.95 - 10.5;
With carbon dioxide; water; In N,N-dimethyl-formamide; for 1.5h; pH=7.6; Product distribution / selectivity;
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sucralose-6-acetate; With sodium hydroxide; water; In N,N-dimethyl-formamide; at 40 ℃; for 4h; pH=10.5;
With carbon dioxide; water; In N,N-dimethyl-formamide; for 0.5h; pH=7.2 - 7.5; Product distribution / selectivity;
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sucralose-6-acetate; With sodium hydroxide; water; In N,N-dimethyl-formamide; at 33.0456 ℃; for 8h; pH=11.1; large scale;
With hydrogenchloride; water; In N,N-dimethyl-formamide; for 0.25h; Product distribution / selectivity;
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sucralose-6-acetate; With calcium hydroxide; water; In N,N-dimethyl-formamide; at 40 ℃; for 2.5h; pH=10.2;
With carbon dioxide; water; In N,N-dimethyl-formamide; pH=5.8 - 6; Product distribution / selectivity;
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In methanol; Product distribution / selectivity;
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With sodium methylate; In methanol; at 30 ℃; for 4h;
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With sodium hydroxide; In N,N-dimethyl-formamide; at 22 ℃; pH=11.7; Product distribution / selectivity;
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sucralose-6-acetate; With water; sodium hydroxide; In N,N-dimethyl-formamide; at 40 ℃; for 4h; pH=10.5;
With hydrogenchloride; water; In N,N-dimethyl-formamide; pH=7; Product distribution / selectivity;
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With sodium hydroxide; In water; pH=9.0 - 9.5;
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With methanol; ammonia; Industry scale;
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With sodium hydroxide; In water; N,N-dimethyl-formamide; at 53 ℃; for 6h; under 40 Torr; pH=12.4;
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With methanol; potassium hydroxide; at 45 ℃; for 4h; pH=11;
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With sodium hypochlorite; water; In methanol; at 0 - 5 ℃; for 4h; pH=12; Solvent; pH-value;
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48 g |
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With Arthrobacter sp. lipase; In aq. buffer; for 96h; Reagent/catalyst; Enzymatic reaction;
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With sodium methylate; In methanol; at 20 ℃; for 4h;
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7.9 g |
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With sodium methylate; In methanol; at 58 - 62 ℃; for 5h; Time;
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141 g |
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With sodium hydroxide; In methanol; at 40 ℃; Temperature; Flow reactor;
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pH=9.0 - 9.5; Product distribution / selectivity;
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With sodium hydroxide; water; pH=9.0 - 9.5; Product distribution / selectivity;
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- 55832-20-7
2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranoside
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- 56038-13-2
Sucralose
| Conditions | Yield |
|---|---|
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2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranoside; With methanol; sodium hydroxide; water; for 0.25h;
In methanol; water; Product distribution / selectivity;
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85% |
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With methanol; sodium methylate; at 15 - 20 ℃; for 5h;
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83% |
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With methanol; sodium carbonate; at 20 ℃; for 2h;
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70% |
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With tetra(n-butyl)ammonium hydroxide; In methanol; at 20 ℃; pH=9;
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68.8% |
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2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranoside; With methanol; sodium methylate; at 20 - 45 ℃; for 1.5h;
With water; acetic acid; at 20 ℃; pH=7.0;
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2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranoside; With methanol; sodium methylate; pH=10.5;
In methanol;
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2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranoside; With methanol; sodium methylate; at 25 - 30 ℃;
Product distribution / selectivity;
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2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranoside; With methanol; sodium methylate; at 10 - 22 ℃; for 0.5 - 4h; pH=8 - 11;
With acetic acid; In methanol; at 22 ℃; Product distribution / selectivity;
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2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranoside; With methanol; sodium hydroxide; water; at 22 ℃; for 0.583333 - 0.833333h; pH=8 - 9;
With acetic acid; In methanol; water; at 22 ℃; pH=6.5 - 7; Product distribution / selectivity;
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56038-13-2 Upstream products
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105066-21-5
sucralose-6-acetate
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56-37-1
N-benzyl-N,N,N-triethylammonium chloride
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936001-72-8
sucrose-6-acetate
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1445-45-0
Trimethyl orthoacetate
56038-13-2 Downstream products
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82920-00-1
3,6-anhydro-4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-anhydro-1,6-dichloro-1,6-dideoxy-β-D-lyxo-hexulofuranoside
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82920-01-2
4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-anhydro-1,6-dichloro-1,6-dideoxy-β-D-lyxo-hexulofuranoside
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55832-20-7
2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranoside
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129747-85-9
2,3-di-O-acetyl-6-O-tert-butyldiphenylsilyl-4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranoside
