CasNo：23828-92-4
Product Name:Ambroxol hydrochloride
Molecular Formula:C13H19Br2ClN2O
Appearance:white crystalline powder
Purity:99%
Factory In Bulk Supply Ambroxol hydrochloride 23828-92-4 with Efficient Shipping
- Molecular Formula:C13H19Br2ClN2O
- Molecular Weight:414.568
- Appearance/Colour:white crystalline powder
- Vapor Pressure:1.61E-10mmHg at 25°C
- Melting Point:233-234.5 °C
- Boiling Point:468.6 °C at 760 mmHg
- Flash Point:237.2 °C
- PSA：58.28000
- Density:1.612 g/cm3
- LogP:4.96100
Ambroxol hydrochloride (Cas 23828-92-4) Usage
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Description |
Ambroxol hydrochloride is an aromatic amine and is a metabolite of bromhexine. Ambroxol hydrochloride is sometimes known as hydrochloric acid bromine cyclohexylamine alcohol. Its chemical name is trans-4-[(2-amino-3,5-dibromo-benzyl) amino] cyclohexanol hydrochloride. |
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Acute toxicity |
Oral-rat LD50: 4203 mg kg; Oral-Mouse LD50: 2380 mg/kg. |
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Chemical Properties |
Ambroxol hydrochloride is a grume dissolving agent, which can help in the breakdown of thick mucus, making it easier to clear from the respiratory tract. |
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Uses |
Ambroxol hydrochloride is indicated for secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport. It promotes mucus clearance, facilitates expectoration, and eases productive cough, allowing patients to breathe freely and deeply. Ambroxol hydrochloride can enhance the concentration of antibiotics in lung tissue when used in combination with them. |
InChI:InChI=1/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H/t10-,11-;
23828-92-4 Relevant articles
Validation of an HPLC method for the quantification of ambroxol hydrochloride and benzoic acid in a syrup as pharmaceutical form stress test for stability evaluation
Maarit Heinänen a, Coral Barbas b
, Journal of Pharmaceutical and Biomedical Analysis Volume 24, Issues 5–6, March 2001, Pages 1005-1010
Ambroxol hydrochloride can be found in pharmaceutical preparations such as drops, granules, injections, syrups and tablets. Several different methods have been used for the individual determination of ambroxol hydrochloride in pharmaceutical solutions and tablets including TLC [3], [4], spectrophotometry [2], HPLC [5], flow injection [6], [7] and capillary electrophoresis.
Stability-Indicating HPTLC Determination of Ambroxol Hydrochloride in Bulk Drug and Pharmaceutical Dosage Form
P.S. Jain
, Journal of Chromatographic Science, Volume 48, Issue 1, January 2010, Pages 45–48,
Stability indicating of new chemical entities is an important part for the drug development of ambroxol hydrochloride and for its estimation in plasma and other biological fluids; the novel Statistical analysis proves that the method is repeatable and selective for the analysis of ambroxol hydrochloride as bulk drug and in pharmaceutical formulations.
23828-92-4 Process route
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- 18683-91-5,36557-04-7,107814-37-9
ambroxol
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- 23828-92-4
ambroxol hydrochloride
| Conditions | Yield |
|---|---|
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With hydrogenchloride; In methanol; for 1h; pH=Ca. 1; Concentration;
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97% |
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With hydrogenchloride; In water; acetone; at 0 ℃; for 1h; Solvent; Temperature;
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97% |
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With hydrogenchloride; In ethyl acetate; for 0.5h;
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86% |
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![trans-4-[(2-amino-3,5-dibromobenzylidene)amino]cyclohexanol](/upload/2023/8/a39b189f-a738-4f32-abf1-b6da91b7f6f3.png)
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trans-4-[(2-amino-3,5-dibromobenzylidene)amino]cyclohexanol
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- 23828-92-4
ambroxol hydrochloride
| Conditions | Yield |
|---|---|
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trans-4-[(2-amino-3,5-dibromobenzylidene)amino]cyclohexanol; With methanol; formic acid; 5%-palladium/activated carbon; at 40 ℃; for 5h; Inert atmosphere; Green chemistry;
With hydrogenchloride; In ethanol; water; at 20 ℃; for 2.5h; Reagent/catalyst; Solvent; Green chemistry;
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95% |
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trans-4-[(2-amino-3,5-dibromobenzylidene)amino]cyclohexanol; With sodium tetrahydroborate; In ethylene glycol; at 20 ℃; for 7h;
With hydrogenchloride; In ethylene glycol; acetone; at 20 ℃; for 2h;
|
|
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trans-4-[(2-amino-3,5-dibromobenzylidene)amino]cyclohexanol; With sodium tetrahydroborate; In ethanol; at 25 ℃;
With hydrogenchloride; In 1,4-dioxane; at 25 ℃;
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> 98 % de |
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